Null Results in Brief Hyaluronan-Mediated Motility Receptor Gene Single Nucleotide Polymorphisms and Risk of Breast Cancer

A recent study used a network modeling strategy to generate a set of genes linked by potential functional associations. The hyaluronan-mediated motility receptor (HMMR) gene was identified as being as functionally associated with BRCA1 and thus a candidate breast cancer gene. SNPs rs10515860, rs299290, and rs7712023 were reported to be significantly associated with breast cancer in a joint analysis of two small case-control studies. We have examined the association of these single nucleotide polymorphisms, together with others tagging the HMMR gene, in a larger, European casecontrol study and find no association of any of themwith risk of breast cancer: rs10515860 [odds ratio (OR; AA/ GG), 0.85; 95% confidence interval (CI), 0.65-1.12; Ptrend = 0.9], rs299290 [OR (CC/TT), 1.00; 95% CI, 0.871.15;Ptrend = 0.7], rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95%CI, 0.84-1.02;Ptrend = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; Ptrend = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; Ptrend = 0.6]. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3618–20)